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Nanoprobes
Nanoprobe公司專業(yè)生產(chǎn)免疫金標記和免疫測定試驗產(chǎn)品。公司建立之初即研發(fā)用于檢測生物分子的最靈敏的試劑和技術(shù)。其獨特的金標技術(shù)使用化學交聯(lián)的金屬和納米顆粒團簇作為標記。與膠體金顆粒靜電吸附在抗體和蛋白質(zhì)上的傳統(tǒng)免疫金探針不同，本公司的金標是與生物分子在特定位點交聯(lián)的不帶電荷的分子。這使我們的探針具有膠體金不具備的范圍和靈活性。

我們的標記可以附著在任何帶有反應基的分子上– 蛋白質(zhì)、多肽、寡核苷酸、小分子和脂類 - 以檢測和定位這些分子。其他標記可以與我們的金標共同使用，我們獨特的熒光納米金探針在一個探針中結(jié)合了納米金（Nanogold?）和熒光素，用于熒光和電鏡兩種技術(shù)共同進行樣品成像。

新探針可基于天然生物分子的一個片段設(shè)計制作，標記可定位于遠離結(jié)合位點處從而不影響探針與目標位點的結(jié)合。

Nanoprobes was founded to develop the most sensitive reagents and technology for detecting biological molecules.

Our unique gold labeling technology uses chemically cross-linked metal clusters and nanoparticles as labels.

Unlike conventional immunogold probes, in which colloidal gold particles are electrostatically adsorbed to antibodies and proteins, our gold labels are uncharged molecules which are cross-linked to specific sites on biomolecules. This gives our probes a range and versatility which is not available with colloidal gold.

Our labels can be attached to any molecule with a reactive group -- proteins, peptides, oligonucleotides, small molecules and lipids -- for detection and localization. Other labels can be combined with our gold labels; our unique FluoroNanogold probes combine Nanogold? and fluorescein into a single probe for imaging a specimen both by fluorescence and electron microscopy.

New probes can be engineered based on any fragment of a naturally occurring biomolecule, and the label can be positioned away from the binding site so it does not interfere with binding.

Our 1.4 nm Nanogold? probes have been cited in over 80 publications, and we are now developing larger cross-linkable labels in order to offer our customers larger covalently linkable probes with the same advantages.